Johnny Sexton is poised to win a 100th cap for Ireland this weekend.
The out-half has been named to captain Andy Farrell's side for the clash with Japan on Saturday.
Jamison Gibson Park is preferred to Conor Murray at scrum half.
Tadhg Furlong will win his 50th cap, while Andrew Porter starts a first international at loosehead.
Garry Ringrose and Connacht's Bundee Aki are the centre pairing, while Connacht's Finlay Bealham is named among the replacements.
The IRFU have confirmed that a number of tickets are still available for the game and are on general sale.