Connacht's Caolin Blade and Paul Boyle could make their senior international debuts on Saturday after they were named in the matchday 23 for Saturday’s Summer Series clash with USA at the Aviva Stadium.
The pair are among four Connacht players on the replacements bench for the game, alongside Dave Heffernan and Finlay Bealham.
There are eight changes to the 15 that started in last weekend's win against Japan.
Four of those are in the back line, with scrum-half Craig Casey partnering Joey Carbery in the half-back line instead of Jamison Gibson-Park.
Mayo's Caelan Doris moves to blindside instead of Peter O'Mahony.
The game gets underway at 7.15 on Saturday evening.
Ireland Team & Replacements (v USA, Vodafone Summer Series, Saturday, July 10, 7:15 pm)
- Hugo Keenan (UCD/Leinster) 12 caps
- Robert Baloucoune (Enniskillen/Ulster) uncapped
- James Hume (Banbridge/Ulster) uncapped
- Stuart McCloskey (Bangor/Ulster) 5 caps
- Andrew Conway (Garryowen/Munster) 24 caps
- Joey Carbery (Clontarf/Munster) 23 caps
- Craig Casey (Shannon/Munster) 2 caps
- Dave Kilcoyne (UL Bohemians/Munster) 44 caps
- Ronan Kelleher (Lansdowne/Leinster) 12 caps
- Tom O'Toole (Ballynahinch/Ulster) uncapped
- Ryan Baird (Dublin University/Leinster) 4 caps
- James Ryan (UCD/Leinster) 36 caps captain
- Caelan Doris (St Mary's College/Leinster) 8 caps
- Nick Timoney (Banbridge/Ulster) uncapped
- Gavin Coombes (Young Munster/Munster) 1 cap
- Dave Heffernan (Buccaneers/Connacht) 5 caps
- Ed Byrne (UCD/Leinster) 5 caps
- Finlay Bealham (Buccaneers/Connacht) 15 caps
- Fineen Wycherley (Young Munster/Munster) uncapped
- Paul Boyle (Buccaneers/Connacht) uncapped
- Caolin Blade (Galwegians/Connacht) uncapped
- Harry Byrne (Lansdowne/Leinster) uncapped
- Will Addison (Enniskillen/Ulster) 4 caps