After earning a point last weekend Sligo Rovers will be aiming to win on the road this evening against Waterford at the RSC.
It kicks off at 7:45 and will be live on RTE television.
Also in the SSE Airtricity League Premier Division this evening Dundalk take on Finn Harps at 5.45 at Oriel Park.
In the First Division, Galway United face a tough opener against Shelbourne, Cork City play Cobh Ramblers, UCD meet Athlone, and it's Wexford versus Cabinteely.
The opening round of fixtures in the SSE Airtricity women's national league sees Galway entertain Cork at 4pm tomorrow.