Head coach Andy Farrell says Ross Byrne deserves his start at out-half against England.
He replaces the injured Jonathan Sexton for the Autumn Nations Cup game at Twickenham on Saturday.
Connacht's Bundee Aki comes in for Robbie Henshaw in the centre, while Keith Earls replaces Andrew Conway on the wing.
CJ Stander replaces Josh van der Flier in the only change to the pack.
Jacob Stockdale and Iain Henderson are both among the replacements.