The Chief Medical Officer has warned that compliance with basic public health measures will be critical in the weeks ahead, as restrictions ease and infection rates remain high.
Dr Tony Holohan was speaking as 2,148 cases of Covid-19 were confirmed yesterday evening.
A further 63 deaths have been notified in the past seven days bringing the total death toll in the State from the virus to 5,369.
Incidence of Covid-19 remains high across the country and is increasing across all age groups.
Dr Holohan reminded people that, while vaccination has helped to prevent many serious illnesses and deaths, the virus still poses a threat, and said "Covid-19 is one of the most contagious viruses we have ever experienced".
The worrying and concerning increase in the number of cases, hospitalisations and admissions to ICU are expected to lead to a rise in the number of deaths reported, said Dr Holohan.