Level five Covid restrictions will come into effect for the whole country at midnight tonight.
People will not be allowed further than 5km from their home unless it's essential or on compassionate grounds, with fines to be introduced in the coming weeks for those breaching the restrictions.
All non-essential retail, hairdressers, barbers and beauty salons must close, while pubs, cafes and restaurants can offer a takeaway service only.
13 additional deaths and 1,269 new cases were confirmed yesterday evening - while the national 14-day incidence rate is just over 279.
In this region, there were 74 new cases confirmed last night in Galway, 28 in Mayo, 27 in Sligo and less than 5 in both Roscommon and Leitrim.
Sligo and Galway both have 14-day incidence rates above the national average - Sligo is at 355 per 100,000 people - which is the 4th highest in the country.
Galway's incidence rate is 313, Roscommon is now 229 and Mayo is at 183 cases per 100,000 people - 5th lowest in the country.
Chief Medical Officer Dr Tony Holohan says everyone needs to take personal responsibility to slow the spread of the virus.