The HSE boss Paul Reid says "there's reason to be hopeful", as the number of patients in hospital with Covid-19 is falling, as well as numbers in ICU.
Nationally today, there are 475 Covid patients being treated in public hospitals, with 112 of those patients in intensive care.
However, the number of Covid-19 patients at Mayo University Hospital remains high, at 38.
This is the 4th highest in the country, after three Dublin hospitals.
Elsewhere, there are 10 Covid patients at UHG, 5 at Sligo University Hospital and 4 at Portiuncla Hospital, Ballinasloe.
In a post on social media, Paul Reid said vaccines are showing positive early signs of effectiveness, as infections among the most vulnerable and healthcare workers are decreasing hugely.
Just over 81,000 Covid-19 vaccines were administered over the past week - lower than the target of 100,000.
The highest daily number was 18,300 given out on Thursday, while less than 2,500 were administered on Sunday.
In total 439,700 injections have taken place, with 141,000 being second doses.