Emergency services are attending the scene of a collision on the outskirts of Tubbercurry.
A truck and two cars were involved in the collision on the Sligo side of Tubbercurry.
Gardai have confirmed that there were injuries sustained, but no further details are yet available.
The N17 Tubbercurry to Sligo road remains closed, and motorists are being diverted via Ballymote.
Meanwhile, Mayo County Council has been dealing with a major fuel spill on the N5 between Ballyvary and the Swinford bypass, and continuing onto the Swinford / Kilkelly road.
Motorists are advised to take caution on these roads.